Boron tribromide → HCID 59283054, compound

Participants

Reaction Conditions

Reaction Steps

To a 10 mL round bottomed flask equipped with a magnetic stir bar containing DCM (5 mL) was placed 264 (0.1 g, 0.3 mmol), the reaction mixture was cooled to 0° C., BBr3 (0.8 mL of 1M in DCM) was added drop wise and was stirred at RT for 3 hrs. The reaction was neutralized with sat. NaHCO3, extracted into DCM (3×15 mL). The combined organic extracts were washed with water (15 mL), brine (15 mL), dried over MgSO4 and concentrated in vacuo. The residue was purified over silica gel using THF:Hexanes (3:2) as an eluent to afford UG-4-69 (0.01 g, 10%) as a white solid.

Provenance & Evidence