4-Bromo-2-fluorophenol → 4-(Benzo[d]thiazol-5-yl)-2-fluorophenol

Participants

Reaction Steps

Compound 4-(benzo[d]thiazol-5-yl)-2-fluorophenol (W121) was prepared using the general procedure for Suzuki coupling reaction between 4-bromo-2-fluorophenol (57 mg, 0.3 mmol) and 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]thiazole (78 mg, 0.3 mmol), as a white solid (45 mg, 61%). 1H NMR (400 MHz, acetone-d6) δ 9.27 (s, 1 H), 8.85 (s, 1 H), 8.28 (d, J=1.6 Hz, 1 H), 8.15 (d, J=8.4 Hz, 1 H), 7.75 (dd, J=8.4, 1.6 Hz 1 H), 7.55 (dd, J=12.4, 2.4 Hz, 1 H), 7.45 (m, 1 H), 7.12 (t, 9.2 Hz, 1 H); MS (ESI) m/z 246 (M+H+).

Provenance & Evidence