2-Benzothiazolamine, 6-bromo- → 6-(3-Fluoro-4-methoxyphenyl)benzo[d]thiazol-2-amine

Participants

Reaction Steps

Compound 6-(3-fluoro-4-methoxyphenyl)benzo[d]thiazol-2-amine (W143) was prepared using the general procedure for Suzuki coupling reaction between 6-bromobenzo[d]thiazol-2-amine (75 mg, 0.3 mmol) and 2-(3-fluoro-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (69 mg, 0.3 mmol), as a white solid (30 mg, 36%). 1H NMR (400 MHz, acetone-d6) δ 7.92 (d, J=2.0 Hz, 1 H), 7.52 (dd, J=8.4, 2.0 Hz, 1 H), 7.47-7.24 (m, 3 H), 7.20 (t, J=8.4 Hz, 1 H), 6.86 (brs, 2 H), 3.92 (s, 3 H); MS (ESI) m/z 275 (M+H+).

Provenance & Evidence