2-Bromo-5-fluoropyridine → HCID 59282943, compound

Participants

Reaction Steps

Compound 5-(5-fluoropyridin-2-yl)benzo[d]thiazole (W208) was prepared using the general procedure for Suzuki coupling reaction between 2-bromo-5-fluoropyridine (39 mg, 0.22 mmol) and 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]thiazole (53 mg, 0.2 mmol), as a white solid (20 mg, 43%). 1H NMR (400 MHz, CDCl3) δ 9.05 (s, 1 H), 8.65 (d, J=1.6 Hz, 1 H), 8.59 (d, J=2.8 Hz, 1 H), 8.14 (dd, J=8.4, 2.0 Hz, 1 H), 8.06 (d, J=8.4 Hz, 1 H), 7.85 (dd, J=8.8, 4.0 Hz, 1 H), 7.52 (td, J=8.4, 2.8 Hz, 1 H); MS (ESI) m/z 231 (M+H+).

Provenance & Evidence