3-Hydroxyphenacyl bromide → HCID 59283019, compound

Participants

Reaction Steps

Compound 3-(7-methoxy-5H-imidazo[1,2-b]indazol-2-yl)phenol (W298) was prepared using the general procedure for cyclization between 6-methoxy-1H-indazol-3-amine (80 mg, 0.5 mmol) and 2-bromo-1-(3-hydroxyphenyl)ethanone (107 mg, 0.55 mmol), as a white solid (40 mg, 22%). 1H NMR (400 MHz, DMSO-d6) δ 9.84 (brs, 1 H), 8.63 (s, 1 H), 7.85 (d, J=9.2 Hz, 1 H), 7.36 (t, J=8.0 Hz, 1 H), 7.31-7.29 (m, 1 H), 7.24 (t, J=2.0 Hz, 1 H), 7.13 (d, J=2.0 Hz, 1 H), 6.99 (dd, J=9.2, 2.0 Hz, 1 H), 6.88 (m, 1 H), 3.90 (s, 3 H); MS (ESI) m/z 280 (M+H+).

Provenance & Evidence