反应详情

To sulfuryl dichloride (5 mL) was added 5-bromobenzo[d]thiazole-2-thiol (450 mg, 1.8 mmol) portionwise. The mixture was stirred at rt for 1 hour and heated at 50° C. for 15 min. After cooling to rt, the reaction mixture was slowly poured onto ice (50 g) and the resulting suspension was stirred for 30 min. Solid was collected through filtration and washed with water (10 mL) and dried under high vacuum to afford 5-bromo-2-chlorobenzo[d]thiazole as a pink solid (470 mg, 100%). MS (ESI) m/z 248 (M+H+).

1. temperatureheated at 50° C. for 15 min
2. temperatureAfter cooling to rt
3. additionthe reaction mixture was slowly poured onto ice (50 g)
4. stirringthe resulting suspension was stirred for 30 min
5. filtrationSolid was collected through filtration
6. washwashed with water (10 mL)
7. customdried under high vacuum