HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → HCID 178419266, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | 5-Methoxy[1,3]thiazolo[5,4-b]pyridin-2-amine | HCID 2801557 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 178419266 | HCID 178419266 | — |
Reaction Steps
5-Methoxythiazolo[5,4-b]pyridin-2-amine (9, 1.0 g, 5.5 mmol) was hydrolyzed with mixture of 48% HBr in water and 45% HBr in acetic acid (4 ml, 1:1) at 135° C. in a pressure bottle for 2 h. The white dihydrobromide salt 10 was filtered and washed with diethyl ether, dried in vacuo 1.7 g (92%). 1H NMR (DMSO-d6): δ 7.64 (1H, m), 6.64 (1H, m); MS: 168 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420052B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-0ea6ae3da6e94c37a5cc0da7286df335 |
| Source note | uspto-grants-2013_04 |