Tricyclo(3.3.1.1'3,7)dec-1-ylmethanol → HCID 68648646, compound

HRID 1965898Notes

Reaction equation

HRID 1965898 reaction equation
[C:1]12([CH2:11][OH:12])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[F:13][C:14]([F:21])([F:20])[C:15](=[CH2:19])[C:16]([OH:18])=[O:17]>>[F:13][C:14]([F:21])([F:20])[C:15](=[CH2:19])[C:16]([O:18][CH:2]([O:12][CH2:11][C:1]12[CH2:8][CH:7]3[CH2:6][CH:5]([CH2:4][CH:3]([CH2:9]3)[CH2:2]1)[CH2:10]2)[CH:1]([CH3:10])[CH3:8])=[O:17]

Participants

3

Reactant 2

HCID 64556Tricyclo(3.3.1.1'3,7)dec-1-ylmethanolHCID 5876942-(Trifluoromethyl)acrylic acid

Product 1

HCID 68648646HCID 68648646, compoundYield 67%

Procedure

By following the same procedures as in Examples 1-1-1 to 1-1-3 aside from using 1-adamantanemethanol instead of 2-adamantanol and 2-(trifluoromethyl)acrylic acid instead of methacrylic acid, 1-[(1-adamantyl)methoxy]-2-methylpropyl 2-(trifluoromethyl)acrylate was produced (four step yield 67%).

Sources & evidence

ORD record
ord-ac1b9cfcaa4e4047acda277b79f802cb
Source dataset
uspto-grants-2013_04
Patent number
US08420290B2

Reaction notes

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