Lithium hydroxide, monohydrate → HCID 43509865, compound

Participants

Reaction Conditions

Reaction Steps

Compound 9 (35.1 g, 0.125 mol) and lithium hydroxide monohydrate (13.0 g, 0.31 mol) were dissolved in 200 mL THF. The reaction mixture was stirred at 80° C. for 12 hours. The mixture was filtered and the homogeneous solution was evaporated to give the crude product. The resulting product was purified by silica gel column chromatography (eluent: ethyl acetate:methylene chloride=1:10 v/v) to yield 26 g (86%) of 4-(9H-carbazol-9-yl)butan-1-ol (Compound 10).

Provenance & Evidence