Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 2,4-Dichloro-5-((trimethylsilyl)ethynyl)pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | Trimethylsilylacetylene | HCID 66111 | — |
| 반응물 | 2,4-Dichloro-5-iodopyrimidine | HCID 263438 | — |
| 촉매 | Palladium Chloride | HCID 24290 | — |
| 촉매 | Copper iodide | HCID 83717 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2,4-Dichloro-5-((trimethylsilyl)ethynyl)pyrimidine | HCID 21080989 | — |
반응 단계
66.55 g of 2,4-dichloro-5-iodo-pyrimidine is stirred for three hours in 1.2 litres of absolute THF with 70 ml of triethylamine, 4.9 g of palladium chloride, 13.3 g of triphenylphosphine, 4 g of copper iodide and 39.3 ml of trimethylsilylacetylene at 40° C. After the reaction has ended the solvent is eliminated in vacuo and the dark red oil remaining is subjected to fractional distillation. The product is distilled over at 0.01 Torr and 100° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08420630B2 |
| 출처 데이터셋 | uspto-grants-2013_04 |
| ORD ID | ord-00803ae75a2e410ca9c6b75faccb1d8e |
| 출처 메모 | uspto-grants-2013_04 |