Water → HCID 21080314, compound

HRID 1965950Notes

Reaction equation

HRID 1965950 reaction equation
Cl.C([N:9]1[CH2:15][CH2:14][CH2:13][C:12](=[O:16])[CH:11]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:10]1)C1C=CC=CC=1.O>CO.[Pd]>[C:17]1([CH:11]2[C:12](=[O:16])[CH2:13][CH2:14][CH2:15][NH:9][CH2:10]2)[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

5

Reactant 2

HCID 962WaterHCID 21080355HCID 21080355, compound

Product 1

HCID 21080314HCID 21080314, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

22.1 g of 1-benzyl-3-phenyl-perhydro-azepin-4-one hydrochloride are dissolved in 250 ml of methanol and 10 ml of water and hydrogenated with 2.5 g of Pd/C (10%) for 3 hours under 5 bar of H2. Then another 2.5 g of catalyst are added and the hydrogenation step is repeated. The catalyst is filtered off and the mixture is evaporated down. The residue is recrystallised from ethanol. Yield: 8.2 g

Workup

  1. filtrationThe catalyst is filtered off
  2. customthe mixture is evaporated down
  3. customThe residue is recrystallised from ethanol

Sources & evidence

ORD record
ord-96d833cca90147a9ad3ddb56ba94b2a9
Source dataset
uspto-grants-2013_04
Patent number
US08420630B2

Reaction notes

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