HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1965952Generated: October 25, 2026
Triethylamine → Methyl 4-[(pyridine-3-ylmethyl)-amino]-cyclohexane-carboxylate
https://huagongshe.com/reaction/1965952
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Pyridinecarboxaldehyde | HCID 10371 | — |
| Reactant | Methyl 4-aminocyclohexanecarboxylate | HCID 422580 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 4-[(pyridine-3-ylmethyl)-amino]-cyclohexane-carboxylate | HCID 68583226 | — |
Reaction Steps
6.13 g of pyridine-3-aldehyde, 5.77 g of triethylamine and 9 g of methyl 4-amino-cyclohexanecarboxylate are mixed into 250 ml of methanol. 3 g of Raney nickel are added thereto in order to hydrogenate the mixture, with stirring, for about 6.5 hours at 50° C. and 3 bar. After the catalyst has been eliminated by suction filtering the filtrate is evaporated down. The crude product is purified through silica gel with methylene chloride/methanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08420630B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-855f39c9cb3c47b1904666b1a086d85d |
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| Source note | uspto-grants-2013_04 |
|---|
