HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Chloroethyl isocyanate → 1-But-3-ynyl-3-(2-chloro-ethyl)-urea
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Chloroethyl isocyanate | HCID 16035 | — |
| Edukt | But-3-yn-1-amine | HCID 10034574 | — |
| Lösungsmittel | Diethyl Ether | HCID 3283 | — |
| Produkt | 1-But-3-ynyl-3-(2-chloro-ethyl)-urea | HCID 59787366 | 100% |
Reaktionsschritte
Add chloroethyl isocyanate (5.25 g, 50 mmol) dropwise to a solution of but3-ynyl-amine (3.4 g, 50 mmol) (prepared by following the procedure described in Tetrahedron Lett. 1987, 43, 5145) in ethyl ether (100 mL). Stir the suspension for 30 min and filter the solid to obtain the desired intermediate (8.7 g, 100%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08420631B2 |
| Quelldatensatz | uspto-grants-2013_04 |
| ORD ID | ord-7a5f8d6b5fc64492901a3aff656875a6 |
| Quellennotiz | uspto-grants-2013_04 |