Triethylamine → (4-{[(Cyclopentanecarbonyl)amino]methyl}phenyl)boronic acid

https://huagongshe.com/reaction/1965966

Participants

Role	Name	HCID	Charge
Reactant	Triethylamine	HCID 8471	—
Reactant	Cyclopentanecarbonyl chloride	HCID 78284	—
Reactant	4-Aminomethylphenylboronic acid hydrochloride	HCID 2734311	—
Solvent	Dichloromethane	HCID 6344	—
Product	(4-{[(Cyclopentanecarbonyl)amino]methyl}phenyl)boronic acid	HCID 59787407	83.4%

Reaction Conditions

Temperature	0 °C

Reaction Steps

Dissolve 4-aminomethylphenyl boronic acid hydrochloride (1.0 g, 5.34 mmol) in DCM (50 mL), add triethylamine (1.64 mL, 11.74 mmol) and cool the mixture to 0° C. Add cyclopentanecarbonyl chloride (778 mg, 5.78 mmol) and warm to room temperature. Stir the reaction mixture for 18 h, filter and wash the solid with DCM (10 mL) to give the title compound as a fine white powder (1.1 g, 83%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08420631B2
Source dataset	uspto-grants-2013_04
ORD ID	ord-e3e48b2f18274d179dfb715f3aa41fbf
Source note	uspto-grants-2013_04