Ethanamine, 2,2,2-trifluoro- → HCID 59787429, compound

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Reaction Steps

Dissolve 3-formylphenyl boronic acid hydrochloride (2.5 g, 16.67 mmol) and 2,2,2,-trifluoroethylamine (2.97 g, 30.01 mmol) in DCM (100 mL). Add sodium triacetoxyborohydride (10.6 g, 50.02 mmol) portionwise over 10 min and stir the resulting solution for 72 h. Then quench with water (50 mw). Dry the organic fraction over MgSO4, filter and concentrate in vacuo. Purify by chromatography on silica gel eluting with dichloromethane:methanol (1:0 to 19:1) to give the title compound as a colourless oil (1.41 g, 36%).

Provenance & Evidence