HCID 59787348, compound → HCID 68857448, compound

Participants

Reaction Steps

Stir 3-tert-butoxycarbonyl-7-chloro-6-(2-methyl-5-phenyl-2H-[1,2,3]triazol-4-yl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine (7.8 mg, 18 μmol) in trifluoroacetic acid (2 mL) at room temperature for 5 h. Concentrate in vacuo and purify the residue by HPLC (Zorbax SB-Phenyl column, 21.2×250 mm; flow rate: 22 mL/min; eluting with 10 to 90% acetonitrile in 0.1% aqueous trifluoroacetic acid). Concentrate in vacuo and elute the residue through a SCX column. Use a method similar to the General Procedure 2-2 and evaporate by lyophylization to obtain the title compound (6 mg, 100%). MS (ES+) m/z: 339 (M+H)+.

Provenance & Evidence