HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-chloro-6-[4-(2,2-dimethyl-propionylamino)-but-1-ynyl]-3-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine → 7-Chloro-6-[4-(2,2-dimethyl-propionylamino)-but-1-ynyl]-2,3,4,5-tetrahydro-1H-benzo[d]azepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-chloro-6-[4-(2,2-dimethyl-propionylamino)-but-1-ynyl]-3-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine | HCID 86622783 | — |
| Solvent | Ammonia | HCID 222 | — |
| Solvent | Methanol tetrahydrofuran water | HCID 21892291 | — |
| Product | 7-Chloro-6-[4-(2,2-dimethyl-propionylamino)-but-1-ynyl]-2,3,4,5-tetrahydro-1H-benzo[d]azepine | HCID 59787421 | 94.4% |
Reaction Steps
Use a method similar to the General Procedure 1-1, using 7N ammonia in methanol/water/THF (10:1:1 ratio) as solvent, to deprotect 7-chloro-6-[4-(2,2-dimethyl-propionylamino)-but-1-ynyl]-3-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine (62 mg, 0.14 mmol) and afford the title compound as an oil (44 mg, 91%). MS (ES+) m/z: 333.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420631B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-ec0b1b9b4dea412498e32a0df7d1fe33 |
| Source note | uspto-grants-2013_04 |