HCID 86622785, compound → HCID 86622786, compound

Participants

Reaction Steps

Dissolve 7-chloro-6-[3-(cyclopentanecarbonyl-amino)-prop-1-ynyl]-3-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine (170 mg, 0.4 mmol) in EtOAc (50 mL) and submit the mixture to hydrogenation over 10% Pd/C (85 mg) at 15 psi for 10 mins. Filter the mixture through Celite® and concentrate the filtrate to give 7-chloro-6-[(Z)-3-(cyclopentanecarbonyl-amino)-propenyl]-3-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine as a pale yellow solid (170 mg).

Provenance & Evidence