Hydrogen chloride-ethyl acetate → HCID 66657204, compound

HRID 1966039Notes

Reaction equation

HRID 1966039 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][C@H:10]([N:13]([C:24]2[CH:29]=[CH:28][C:27]([F:30])=[C:26]([Cl:31])[CH:25]=2)[C:14]2[CH:19]=[CH:18][C:17]([S:20]([CH3:23])(=[O:22])=[O:21])=[CH:16][CH:15]=2)[CH2:9]1)=O)(C)(C)C.Cl.C(OCC)(=O)C>>[ClH:31].[Cl:31][C:26]1[CH:25]=[C:24]([N:13]([C:14]2[CH:19]=[CH:18][C:17]([S:20]([CH3:23])(=[O:22])=[O:21])=[CH:16][CH:15]=2)[C@H:10]2[CH2:11][CH2:12][NH:8][CH2:9]2)[CH:29]=[CH:28][C:27]=1[F:30]

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 66657182HCID 66657182, compound

Product 1

HCID 66657204HCID 66657204, compoundYield 191.9%

Procedure

3(S)-[(3-chloro-4-fluorophenyl)-(4-methanesulfonylphenyl)amino]pyrrolidine-1-carboxylic acid tert-butyl ester (0.42 g, 0.9 mmol) was added to 4 N hydrochloric acid/ethyl acetate, followed by stirring at room temperature for one hour. The reaction solution was concentrated to dryness under reduced pressure to thereby obtain 0.35 g of white powdery (3-chloro-4-fluorophenyl)-(4-methanesulfonylphenyl)-(S)-pyrrolidin-3-ylamine hydrochloride.

Workup

  1. concentrationThe reaction solution was concentrated to dryness under reduced pressure

Sources & evidence

ORD record
ord-fe6070a405894696a9b0d1ced5e9f268
Source dataset
uspto-grants-2013_04
Patent number
US08420623B2

Reaction notes

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