HCID 49849199, compound → HCID 49849200, compound

HRID 1966109Notes

Reaction equation

[C:1]([C:3]1[CH:4]=[C:5]([CH:33]=[CH:34][CH:35]=1)COC1C=CC(S(NC[C@H](N2CCN(S(C)(=O)=O)CC2)C(O)=O)(=O)=O)=CC=1)#[N:2].C(C1C=C(C=CC=1)[CH2:41][O:42][C:43]1[CH:48]=[CH:47][C:46]([S:49]([NH:52][CH2:53][C@H:54]([N:59]2[CH2:64][CH2:63][N:62]([S:65]([CH3:68])(=[O:67])=[O:66])[CH2:61][CH2:60]2)[C:55]([NH:57][OH:58])=[O:56])(=[O:51])=[O:50])=[CH:45][CH:44]=1)#N>>[C:1]([C:3]1[CH:4]=[CH:5][C:33]([CH2:41][O:42][C:43]2[CH:48]=[CH:47][C:46]([S:49]([NH:52][CH2:53][C@H:54]([N:59]3[CH2:60][CH2:61][N:62]([S:65]([CH3:68])(=[O:66])=[O:67])[CH2:63][CH2:64]3)[C:55]([NH:57][OH:58])=[O:56])(=[O:50])=[O:51])=[CH:45][CH:44]=2)=[CH:34][CH:35]=1)#[N:2]

Participants

Reactant 2

HCID 49849199HCID 49849199, compound

HCID 66870983HCID 66870983, compound

Product 1

HCID 49849200HCID 49849200, compound

Procedure

In a manner analogous to example 3.8, using 264 mg (0.5 mmol) of (S)-3-[4-(3-cyanobenzyloxy)benzenesulfonylamino]-2-(4-methanesulfonylpiperazin-1-yl)propanoic acid, 107 mg (40%) of (S)-3-[4-(3-cyanobenzyloxy)benzenesulfonylamino]-N-hydroxy-2-(4-methanesulfonyl-piperazin-1-yl)propionamide are obtained in the form of a beige powder with a melting point of 108° C.

Workup

customare obtained in the form of a beige powder with a melting point of 108° C.

Sources & evidence

ORD record: ord-0c6137d4d32a47a288076796684aedd7
Source dataset: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08420632B2

Reaction notes

Loading…