HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1966154Generated: October 30, 2026
Dimethylformamide → 1-(Cyanomethyl)-3-methylenecyclobutanecarbonitrile
https://huagongshe.com/reaction/1966154
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | (1-Cyano-3-methylenecyclobutyl)methyl methanesulfonate | HCID 86634345 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-(Cyanomethyl)-3-methylenecyclobutanecarbonitrile | HCID 66824383 | — |
Reaction Steps
A mixture of (1-cyano-3-methylenecyclobutyl)methyl methanesulfonate (0.41 g, 0.0020 mol) and potassium cyanide (0.66 g, 0.010 mol) in N,N-dimethylformamide (5 mL, 0.06 mol) was heated at 65° C. overnight. After diluting with water, the resulting mixture was extracted with EtOAc. The combined organic layers were washed with water, brine, dried and evaporated to dry. The residue was used directly in next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08420629B2 |
|---|
| Source dataset | uspto-grants-2013_04 |
|---|
| ORD ID | ord-39663aa97586452ca0f4c81c898b239e |
|---|
| Source note | uspto-grants-2013_04 |
|---|
