反应详情

A mixture of 5-hexenimidamide hydrochloride (P4, 500 mg), 3-phenyl-2-propynal (398 mg), and sodium carbonate (786 mg) in acetonitrile (15 mL) was irradiated in a microwave synthesizer at 120° C. for 40 min and then allowed to cool. The solution was filtered and evaporated in vacuo. The residue was dissolved in dichloromethane and the organic layer was washed with H2O, dried over Na2SO4, filtered and evaporated in vacuo. The crude was purified by column chromatography (eluting with ciclohexane/ethyl acetate 9/1) to give 142 mg of the title compound.

1. customwas irradiated in a microwave synthesizer at 120° C. for 40 min
2. temperatureto cool
3. filtrationThe solution was filtered
4. customevaporated in vacuo
5. dissolutionThe residue was dissolved in dichloromethane
6. washthe organic layer was washed with H2O
7. dry with materialdried over Na2SO4
8. filtrationfiltered
9. customevaporated in vacuo
10. customThe crude was purified by column chromatography (eluting with ciclohexane/ethyl acetate 9/1)