Sodium Hydroxide → HCID 25260859, compound

HRID 1966204Notes

Reaction equation

HRID 1966204 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]2[S:10][CH:11]=[C:12]([CH2:14][O:15]C(=O)C)[N:13]=2)=[N:6][CH:7]=1.[OH-].[Na+]>C(O)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]2[S:10][CH:11]=[C:12]([CH2:14][OH:15])[N:13]=2)=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 25261015HCID 25261015, compound

Product 1

HCID 25260859HCID 25260859, compoundYield 56%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Acetic acid 2-(5-bromo-pyridine-2-yl amino)-thiazole-4-ylmethyl ester (0.29 mmol) is suspended in ethanol (1 ml) and 1 M NaOH (1 ml) is added. The suspension is stirred at RT for 75 min. The precipitate is filtered, washed with water and dried 16 h in vacuo at 40° C. “A6” is obtained as a colourless powder in a yield of 56%; mp. 207.0-209.0° C.; HPLC (method C): 1.41 min); LC-MS (method A): 1.222 min, 285.95 (M+H+);

Workup

  1. filtrationThe precipitate is filtered
  2. washwashed with water
  3. dry with materialdried 16 h in vacuo at 40° C. “A6”
  4. customis obtained as a colourless powder in a yield of 56%
  5. custom1.41 min
  6. custom1.222 min, 285.95 (M+H+)

Sources & evidence

ORD record
ord-7801b78bf27448b2b31989d2f15b5962
Source dataset
uspto-grants-2013_04
Patent number
US08420642B2

Reaction notes

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