Chloroacetaldehyde → HCID 25261014, compound

Participants

Reaction Conditions

Reaction Steps

8.4 (5-Phenoxy-pyridine-2-yl)-thiourea (0.3 mmol) is dissolved in DMF (1 ml) and chloro-acetaldehyde (1.1 eq., 55% in water) is added and stirred 2 h at 70° C. After cooling to RT the precipitate is filtered, washed with water and dried 16 h in vacuo at 40° C. (5-Phenoxy-pyridine-2-yl)thiazole-2-yl-amine is obtained as colourless powder in a yield of 66%; mp. 161.4-162.4° C.; HPLC (method C): 1.69 min; LC-MS (method A): 1.559 min, 270.15 (M+H+); 1H-NMR (DMSO-d6, 500 MHz): δ [ppm] 11.248 (s, 1H), 8.114 (d, 1H, J=2.7 Hz), 7.523 (dd, 1H, J=9.0 Hz, J=2.7 Hz), 7.387-7.355 (m, 3H), 7.151 (d, 1H, J=9.0 Hz), 7.107 (t, 1H, J=7.1 Hz), 6.997-6.967 (m, 3H).

Provenance & Evidence