Sodium Hydroxide → HCID 25261018, compound

Participants

Reaction Steps

Acetic acid 2-(5-phenoxy-pyridine-2-ylamino)-thiazole-4-ylmethyl ester (0.44 mmol) is suspended in ethanol (1.5 ml) and 1 M NaOH (1.5 ml) is added. The solution is stirred at RT for 3 h. The reaction solution is diluted with water. The precipitate is filtered, washed with water and dried 16 h in vacuo at 40° C. “A10” is obtained as a beige powder in yield of 88%; mp. 130.0-131.0° C.; HPLC (method C): 1.64 min; LC-MS (method A): 1.430 min, 300.15 (M+H+); 1H-NMR (DMSO-d6, 400 MHz): δ [ppm] 11.221 (s, 1H), 8.102 (d, 1H, J=2.8 Hz), 7.515 (dd, 1H, J=8.9 Hz, J=2.8 Hz), 7.389-7.349 (m, 2H), 7.125-7.083 (m, 2H), 6.996-6.972 (s, 2H), 6.687 (s, 1H), 5.105 (t, 1H, J=5.3 Hz), 4.442 (d, 2H, J=5.3 Hz).

Provenance & Evidence