Disodium disulfite → HCID 25261021, compound

Participants

Reaction Conditions

Reaction Steps

(5-Phenylsulfanyl-pyridine-2-yl)-thiazole-2-yl-amine (0.13 mmol) is dissolved in dichloromethane, cooled to 0° C. and m-chloro-perbenzoic acid (1 eq.) is added. The reaction is stirred 30 min at 0° C. and 2.5 hours at RT. Sodium disulfite (50 ml) is added and extracted with dichloromethane. The combined organic layers are washed with saturated NaHCO3, dried over MgSO4 and the solvent is removed in vacuo. “A13” is obtained after reversed phase column chromatography (water/acetonitrile) as a yellow powder in a yield of 44% HPLC (method C): 1.41 min; LC-MS (method A): 1.223 min, 301.95 (M+H+); 1H-NMR (DMSO-d6, 500 MHz): δ [ppm] 11.657 (s, 1H), 8.634-8.628 (m, 1H), 7.853 (dd, 1H, J=2.4 Hz, J=8.9 Hz), 7.722-7.703 (m, 2H), 7.583-7.507 (m, 3H), 7.425 (d, 1H, J=3.6 Hz), 7.152 (d, 1H, J=8.9 Hz), 7.100 (d, 1H, J=3.6 Hz).

Provenance & Evidence