Chloroacetaldehyde → HCID 25261177, compound

Participants

Reaction Conditions

Reaction Steps

(3-Cyclopentyloxy-5-phenoxy-pyridine-2-yl)-thiourea (0.29 mmol) is dissolved in DMF (1 ml) and chloro-acetaldehyde (1.1 eq., 55% in water) is added and stirred 3 h at 100° C. After cooling to room temperature the suspension is pored into ice-water and extracted with methyl-ter.-butyl ether. The combined organic phases are washed with brine and dried over MgSO4. The solvent is removed in vacuo. (3-Cyclopentyloxy-5-phenoxy-pyridine-2-yl)-thiazole-2-yl-amine (“A21”) is obtained after reversed phase chromatography (water/acetonitrile+0.1% TFA) as yellow solid in a yield of 47%; 138.2-139.7°; HPLC (method C): 2.00 min; LC-MS (method A): 2.00 min, 354.1 (M+H+);

Provenance & Evidence