HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1966237Generated: October 30, 2026
1-Methoxy-2-propanol → 5-Chloro-3-(2-methoxy-1-methyl-ethoxy)-2-nitro-pyridine
https://huagongshe.com/reaction/1966237
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Methoxy-2-propanol | HCID 7900 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 5-Chloro-2-nitropyridin-3-ol | HCID 18765698 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-Chloro-3-(2-methoxy-1-methyl-ethoxy)-2-nitro-pyridine | HCID 67486418 | 100% |
Reaction Steps
5-Chloro-2-nitro-pyridine-3-ol (5.7 mmol) is dissolved in THF (35 ml) and triphenylphosphin (2 eq.) and 1-Methoxy-2-propanol (1 eq.) is added at 0° C. After addition of di-tert.-butylazodicarboxylate (1.5 eq) in THF (10 ml), the reaction is stirred five hours at 0° C. The solvent is removed in vacuo. 5-Chloro-3-(2-methoxy-1-methyl-ethoxy)-2-nitro-pyridine is obtained after column chromatography (heptan/ethylacetate) as yellow solid in a yield of 100%. HPLC (method C): 1.81 min; LC-MS (method A): 1.64 min, 247.05 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08420642B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-9b6d110d96304d60bf42e7dcd21dd991 |
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| Source note | uspto-grants-2013_04 |
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