反应详情

温度

105 °C

In a pressure tube, 8-aminobenzo[c]chromen-6-one (Reference Compound No. 1-1-(2), 8.81 g, 41.7 mmol) was dissolved in acetone (300 ml . . . ), then iodine (4.24 g, 16.7 mmol) was added thereto, then the pressure tube was sealed, and then the reaction mixture was stirred at 105° C. for 2 days. After cooling down, the solvent was removed under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane-ethyl acetate) to give the titled reference compound (4.83 g) as a yellow solid. (Yield 40%)

1. customthe pressure tube was sealed
2. temperatureAfter cooling down
3. customthe solvent was removed under reduced pressure
4. customThe obtained residue was purified by silica gel column chromatography (hexane-ethyl acetate)