Hydrochloric Acid → HCID 58027116, compound

Participants

Reaction Steps

Methyl 2-(2,3,4-trifluorophenyl)-5-nitrobenzoate (Reference Compound No. 1-2-(1), 4.37 g, 14.1 mmol) was dissolved in a mixture of tetrahydrofuran (10 mL) and methanol (30 mL), then 1N aqueous NaOH solution (20 mL) was added thereto, and then the reaction mixture was stirred at room temperature overnight. Water (150 mL) and 1N aqueous HCl solution (30 mL) were added to the reaction mixture to acidify, then ethyl acetate (150 mL) was added thereto, and then separated. The organic layer was washed with saturated brine (150 mL), dried over anhydrous magnesium sulfate, and then the solvent was removed under reduced pressure to give the titled reference compound (4.18 g) as a gray solid. (Yield 100%)

Provenance & Evidence