HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → Morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-(4-Bromophenyl)-1-morpholinoethanone | HCID 875880 | — |
| Product | Morpholine | HCID 8083 | — |
| Product | Benzeneacetyl chloride, 4-bromo- | HCID 181552 | — |
Reaction Steps
The compound shown on the left above, 2-(4-bromo-phenyl)-1-morpholin-4-yl-ethanone, is obtained by reaction of the corresponding acid chloride (A), (4-bromo-phenyl)-acetyl chloride, with morpholine and Et3N in DCM at rt. The product is obtained in high yield. The intermediate acid chloride (A) is obtained by reaction of (4-bromo-phenyl)-acetic acid (B) and oxalyl chloride (C) in DCM at rt and using DMF as reaction initiator. The intermediate (A) is obtained in good yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420657B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-9280a041ff484844a75c851808f0414b |
| Source note | uspto-grants-2013_04 |