HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrabutylammonium Fluoride → HCID 57820506, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | 2-((Tert-butyldimethylsilyl)oxy)acetaldehyde | HCID 4187788 | — |
| Reactant | HCID 57820172 | HCID 57820172 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Sodium cyanoborohydride | HCID 5003444 | — |
| Product | HCID 57820506 | HCID 57820506 | — |
Reaction Steps
The compound is obtained by treating [7-(3,5-Difluoro-4-morpholin-4-ylmethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-((S)-4-morpholin-3-yl-phenyl)-amine (Example 511) with (tert-butyldimethylsilyloxy)-acetaldehyde in methanol and sodium cyanoborohydride at 60° C., followed by a deprotection with TBAF in THF. HPLC: tR=0.60 min (Method G); MS-ES: (M+H)+=551
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420657B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-5a148d9181b5436ab2582d56b69f3707 |
| Source note | uspto-grants-2013_04 |