Benzyl Bromide → HCID 46198774, compound

Participants

Reaction Steps

A suspension of 5-(4-benzoylpiperazin-1-yl)-2-nitro-N-phenylbenzenamine (1.0 g, 2.5 mmol), benzylbromide (0.3 ml, 2.5 mmol), potassium hydroxide (0.18 g, 3.2 mmol) and tetra-butyl ammonium iodide (0.05 g, 0.25 mmol) in 40 ml toluene was stirred at room temperature overnight. The red solids were filtered to get N-benzyl-5-(4-benzoylpiperazin-1-yl)-2-nitro-N-phenylbenzenamine (1.1 g, 90%). 1H NMR (500 MHz, DMSO-d6) δ (ppm) 3.40-3.58 (m, br, 8H), 4.94 (s, 2H), 6.30 (d, J=8.0 Hz, 2H), 6.73 (t, J=7.2 Hz, 1H), 6.88 (d, J=9.2 Hz, 2H), 7.09-7.48 (m, 12H), 7.98 (d, J=8.9 Hz, 1H).

Provenance & Evidence