HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1966493Generated: October 31, 2026
2-Pyrazinecarboxylic acid → HCID 45110639, compound
https://huagongshe.com/reaction/1966493
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Pyrazinecarboxylic acid | HCID 1047 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 68499875 | HCID 68499875 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 45110639 | HCID 45110639 | 44% |
Reaction Steps
To a solution of Example 25a (320 mg, 0.47 mmol) in dimethylformamide (5 mL) was added pyrazinecarboxylic acid (0.065 g, 0.52 mmol), HATU (214 mg, 0.56 mmol) and diisopropylethylamine (0.2 mL, 1.18 mmol). The reaction mixture was stirred at 25° C. for 2 h and then partitioned between 5% aqueous sodium bicarbonate and ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, filtered, and evaporated. The residue was purified by crystallization from ethyl acetate/hexane to give the desired product (155 mg, 44% yield) as an off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08420596B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-575031f756c449c7be0001994404058a |
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| Source note | uspto-grants-2013_04 |
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