HRID1966499

反应详情

EQUATION

反应方程式

REACTANTS

反应物

$结构：CCOC(=O)[C@@]12C[C@H]1/C=C\CCCCC[C@H](NC(=O)OC(C)(C)C)C(=O)N1C[C@H](Oc3nc4ccccc4c4ccccc34)C[C@H]1C(=O)N2$

HCID68499992

未命名化合物

$结构：CCOC(=O)[C@@]12C[C@H]1/C=C\CCCCC[C@H](NC(=O)OC(C)(C)C)C(=O)N1C[C@H](Oc3nc4ccc(F)cc4c4cc(F)ccc34)C[C@H]1C(=O)N2$

HCID68500409

未命名化合物

PRODUCTS

生成物

$结构：CC(C)(C)OC(=O)N[C@H]1CCCCC/C=C\[C@@H]2C[C@@]2(C(=O)O)NC(=O)[C@@H]2C[C@@H](Oc3nc4ccc(F)cc4c4cc(F)ccc34)CN2C1=O$

HCID68499747

未命名化合物

PROCEDURE

实验过程

Example 38e was prepared according to the procedure used for the preparation of Example 24c, substituting the product of Example 38d for the product of Example 24b.

WORKUP

后处理

customExample 38e was prepared
customused for the preparation of Example 24c

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-af223d1a655543e28e4c6fa705c6ec30
来源数据集: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08420596B2
来源说明: uspto-grants-2013_04

反应 SMILES

[C:1]([O:5][C:6]([NH:8][C@@H:9]1[C:23](=[O:24])[N:22]2[CH2:25][C@H:26]([O:28][C:29]3[N:30]=[C:31]4[C:36](=[C:37]5[C:42]=3[CH:41]=[CH:40][C:39]([F:43])=[CH:38]5)[CH:35]=[C:34]([F:44])[CH:33]=[CH:32]4)[CH2:27][C@H:21]2[C:20](=[O:45])[NH:19][C@:18]2([C:47]([O:49]CC)=[O:48])[CH2:46][C@H:17]2[CH:16]=[CH:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(OC(N[C@@H]1C(=O)N2C[C@H](OC3N=C4C(=C5C=3C=CC=C5)C=CC=C4)C[C@H]2C(=O)N[C@]2(C(OCC)=O)C[C@H]2C=CCCCCC1)=O)(C)(C)C>>[C:1]([O:5][C:6]([NH:8][C@@H:9]1[C:23](=[O:24])[N:22]2[CH2:25][C@H:26]([O:28][C:29]3[N:30]=[C:31]4[C:36](=[C:37]5[C:42]=3[CH:41]=[CH:40][C:39]([F:43])=[CH:38]5)[CH:35]=[C:34]([F:44])[CH:33]=[CH:32]4)[CH2:27][C@H:21]2[C:20](=[O:45])[NH:19][C@:18]2([C:47]([OH:49])=[O:48])[CH2:46][C@H:17]2[CH:16]=[CH:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]