Hydrogen Bromide → HCID 68493794, compound

Participants

Reaction Conditions

Reaction Steps

(3,4-Dichlorobenzyl)-{2-methyl-8-[4-(toluene-4-sulfonyl)-piperazin-1-yl]-quinolin-4-yl}-amine (example 17, 40 mg, 0.072 mmole) and a mixture of HBr/glacial acetic acid (33%, 1 mL)/0.2 mL) were stirred at 70° C. for 3 hrs. The content of the flask was diluted with water and extracted with ethyl acetate. The aqueous phase was alkalized and extracted with dichloromethane. The organic phases were washed with saturated NaCl solution and concentrated. The residue was crystallized as hydrochloride from isopropanol/iso-propyl ether/ethanol/HCl to give a light fawn salt (17 mg, 50%).

Provenance & Evidence