2,4-Dichlorobenzylamine → [8-(2-Aminoethoxy)-2-methylquinolin-4-yl]-(2,4-dichlorobenzyl)-amine

HRID 1966525Notes

Reaction equation

HRID 1966525 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][O:10][C:11]1[CH:12]=[CH:13][CH:14]=[C:15]2[C:20]=1[N:19]=[C:18]([CH3:21])[CH:17]=[C:16]2Cl)(C)(C)C.[Cl:24][C:25]1[CH:32]=[C:31]([Cl:33])[CH:30]=[CH:29][C:26]=1[CH2:27][NH2:28]>>[NH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:12]=[CH:13][CH:14]=[C:15]2[C:20]=1[N:19]=[C:18]([CH3:21])[CH:17]=[C:16]2[NH:28][CH2:27][C:26]1[CH:29]=[CH:30][C:31]([Cl:33])=[CH:32][C:25]=1[Cl:24]

Participants

3

Reactant 2

HCID 14852,4-DichlorobenzylamineHCID 59474799[2-(4-Chloro-2-methylquinolin-8-yloxy)-ethyl]-carbamate tert-butyl ester

Product 1

HCID 59474801[8-(2-Aminoethoxy)-2-methylquinolin-4-yl]-(2,4-dichlorobenzyl)-amine

Procedure

Preparation was made using a similar procedure as described in example 20. Starting materials were [2-(4-chloro-2-methylquinoline-8-yloxy)-ethyl]-carbamate tert-butyl ester and 2,4-dichlorobenzylamine.

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-d1dc9df1bb8240ad8e80ce6637aab011
Source dataset
uspto-grants-2013_04
Patent number
US08420670B2

Reaction notes

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