Methyl iodide → 1-(3-Fluoro-5-iodo-pyridin-2-yl)-3,4,4-trimethyl-imidazolidin-2-one

HRID 1966587Notes

Reaction equation

[F:1][C:2]1[C:3]([N:9]2[CH2:13][C:12]([CH3:15])([CH3:14])[NH:11][C:10]2=[O:16])=[N:4][CH:5]=[C:6]([I:8])[CH:7]=1.I[CH3:18]>>[F:1][C:2]1[C:3]([N:9]2[CH2:13][C:12]([CH3:14])([CH3:15])[N:11]([CH3:18])[C:10]2=[O:16])=[N:4][CH:5]=[C:6]([I:8])[CH:7]=1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 575167531-(3-Fluoro-5-iodo-pyridin-2-yl)-4,4-dimethyl-imidazolidin-2-one

Product 1

HCID 575167541-(3-Fluoro-5-iodo-pyridin-2-yl)-3,4,4-trimethyl-imidazolidin-2-one

Procedure

The title compound, a yellow oil, MS: m/e=350.0 (M+H+), was prepared in accordance with the general method of Example 16 from 1-(3-fluoro-5-iodo-pyridin-2-yl)-4,4-dimethyl-imidazolidin-2-one (Example 110, step 1) and iodomethane.

Sources & evidence

ORD record: ord-ee80412749914c7f8464ffd5f674bd73
Source dataset: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08420661B2

Reaction notes

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