HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1966626Generated: November 1, 2026
Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester → Ethyl (2E)-4,4-difluoro-4-phenylbut-2-enoate
https://huagongshe.com/reaction/1966626
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester | HCID 70670 | — |
| Reactant | α,α-Difluorobenzeneacetaldehyde | HCID 14644933 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Ethyl (2E)-4,4-difluoro-4-phenylbut-2-enoate | HCID 67244021 | — |
Reaction Steps
Intermediate 19 (0.88 g, 5.64 mmol) was dissolved in THF (12 mL) and (carbethoxymethylene) triphenylphosphorane (1.96 g, 5.64 mmol) was then added. The solution was stirred at 50° C. for 12 hours. The mixture was concentrated and the residue was purified by column chromatography on silica gel using n-hexane/AcOEt (5:1) as eluent. The title compound was obtained (1.10 g, 89%) as pale yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08420669B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-64f68e8880d349e9b7e1cef57995f297 |
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| Source note | uspto-grants-2013_04 |
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