2,2-Difluoro-4-phenylbutan-1-ol → 4,4-Difluoro-4-phenylbutan-1-ol

HRID 1966628Notes

Reaction equation

HRID 1966628 reaction equation
[F:1][C:2]([F:16])([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:3][CH2:4][C:5](OCC)=[O:6].FC(F)(CCC1C=CC=CC=1)CO>>[F:1][C:2]([F:16])([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:3][CH2:4][CH2:5][OH:6]

Participants

3

Reactant 2

HCID 184257752,2-Difluoro-4-phenylbutan-1-olHCID 67245996Ethyl 4,4-difluoro-4-phenylbutanoate

Product 1

HCID 571690084,4-Difluoro-4-phenylbutan-1-ol

Procedure

Obtained from Intermediate 21 (0.9 g, 4.1 mmol) by the procedure described in Intermediate 2. The title compound was obtained as oil (0.65 g, 85%).

Sources & evidence

ORD record
ord-96ebd71d795640618e33b22407910acc
Source dataset
uspto-grants-2013_04
Patent number
US08420669B2

Reaction notes

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