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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1966640Generated: October 31, 2026

2,2-Difluoro-4-phenylbutan-1-ol → 4,4,5,5-Tetrafluoro-6-(3-phenylpropoxy)hexan-1-ol

https://huagongshe.com/reaction/1966640

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,2-Difluoro-4-phenylbutan-1-olHCID 18425775—
ReactantEthyl 4,4,5,5-tetrafluoro-6-(3-phenylpropoxy)hexanoateHCID 86658312—
Product4,4,5,5-Tetrafluoro-6-(3-phenylpropoxy)hexan-1-olHCID 8665831182%

Reaction Steps

Obtained from Intermediate 40 (1.0 g, 2.85 mmol) by the procedure described in Intermediate 2. Purification by column chromatography with silica gel and n-hexane/ethyl acetate (from 10:1 to 5:1) as eluent gave the title compound (0.68 g, 82%) as oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08420669B2
Source datasetuspto-grants-2013_04
ORD IDord-617411e14a584288a477dd57c4e966b6
Source noteuspto-grants-2013_04