HCID 67245149, compound → HCID 67245686, compound

HRID 1966646Notes

Reaction equation

HRID 1966646 reaction equation
C([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][O:15][CH2:16][C:17]([C:20]1[CH:21]=[C:22]([N:26]2[C:30](=[O:31])[CH2:29][NH:28][C:27]2=[O:32])[CH:23]=[CH:24][CH:25]=1)([F:19])[F:18])C1C=CC=CC=1>C(O)C.[Pd]>[F:19][C:17]([C:20]1[CH:21]=[C:22]([N:26]2[C:30](=[O:31])[CH2:29][NH:28][C:27]2=[O:32])[CH:23]=[CH:24][CH:25]=1)([F:18])[CH2:16][O:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][OH:8]

Participants

4

Reactant 1

HCID 67245149HCID 67245149, compound

Product 1

HCID 67245686HCID 67245686, compoundYield 96.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of Intermediate 61 (2.52 g, 5.65 mmol) in ethanol (120 mL) was added palladium on charcoal (300 mg). The mixture was hidrogenated at 40 psi for 4 hours. The catalyst was filtered through Celite and the solvent removed under pressure to give the title compound (1.94 g, 96%) as oil.

Workup

  1. filtrationThe catalyst was filtered through Celite
  2. customthe solvent removed under pressure

Sources & evidence

ORD record
ord-90f35c295eba439cada1c4a160cda0f7
Source dataset
uspto-grants-2013_04
Patent number
US08420669B2

Reaction notes

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