HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,3-Difluoro-3-phenylpropan-1-ol → 6-Bromohexyl 3,3-difluoro-3-phenylpropyl ether
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,3-Difluoro-3-phenylpropan-1-ol | HCID 57577082 | — |
| Reactant | 1-(2-[(6-Bromohexyl)oxy]-1,1-difluoroethyl)-3-methoxybenzene | HCID 67245384 | — |
| Product | 6-Bromohexyl 3,3-difluoro-3-phenylpropyl ether | HCID 67246264 | — |
Reaction Steps
Obtained from Intermediate 77 (0.41 g, 0.83 mmol) by the procedure described in Intermediate 69. The resulting oil was purified by column chromatography with silica gel eluting with n-hexane/ethyl acetate (from pure n-hexane to 9:1) to give the title compound (0.85 g of 66% purity, 64%) as oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420669B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-327ada8af73d46c89f07d28a7c1daf92 |
| Source note | uspto-grants-2013_04 |