HuagongsheHuagongshe Chemistry Print Report · For research reference only
Allyl 2,2-difluoro-2-phenylethyl ether → 3-(2,2-Difluoro-2-phenylethoxy)propan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Allyl 2,2-difluoro-2-phenylethyl ether | HCID 67245471 | — |
| Reactant | 3-(4-Phenylbutoxy)propan-1-ol | HCID 67246528 | — |
| Product | 3-(2,2-Difluoro-2-phenylethoxy)propan-1-ol | HCID 67245950 | 96% |
Reaction Steps
Obtained from Intermediate 80 (10.6 g, 53 mmol) by the procedure described in Intermediate 12. Purification by column chromatography with silica gel eluting with ethyl acetate/n-hexane (from 1:4 to pute ethyl acetate) gave the title compound (10.7 g, 96%) as oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420669B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-f78d787b21954680ac0886ca143c3fb2 |
| Source note | uspto-grants-2013_04 |