HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Phenylbutoxy)hept-6-en-3-ol → 1-(2,2-Difluoro-2-phenylethoxy)hept-6-en-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Phenylbutoxy)hept-6-en-3-ol | HCID 67244432 | — |
| Reactant | 3-(2,2-Difluoro-2-phenylethoxy)propanal | HCID 86658313 | — |
| Product | 1-(2,2-Difluoro-2-phenylethoxy)hept-6-en-3-ol | HCID 67245398 | 53% |
Reaction Steps
Obtained from Intermediate 82 (1.86 g, 8.7 mmol) by the procedure described in Intermediate 14. Purification by column chromatography with silica gel eluting with ethyl acetate/n-hexane (1:6) gave the title compound (1.24 g, 53%) as oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08420669B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-74748bd3a73b4801ac2509a0c26007e9 |
| Source note | uspto-grants-2013_04 |