5-[1-tert-Butyl-2-(2-1,2,4-triazol-1-yl-5-vinyl-phenyl)-1H-benzimidazol-5-yl]-pyrimidin-2-ylamine → 5-[1-tert-Butyl-2-(5-ethyl-2-1,2,4-triazol-1-yl-phenyl)-1H-benzimidazol-5-yl]-pyrimidin-2-ylamine

HRID 1966673Notes

Reaction equation

HRID 1966673 reaction equation
[C:1]([N:5]1[C:9]2[CH:10]=[CH:11][C:12]([C:14]3[CH:15]=[N:16][C:17]([NH2:20])=[N:18][CH:19]=3)=[CH:13][C:8]=2[N:7]=[C:6]1[C:21]1[CH:26]=[C:25]([CH:27]=[CH2:28])[CH:24]=[CH:23][C:22]=1[N:29]1[CH:33]=[N:32][CH:31]=[N:30]1)([CH3:4])([CH3:3])[CH3:2]>CCO.[Pd]>[C:1]([N:5]1[C:9]2[CH:10]=[CH:11][C:12]([C:14]3[CH:15]=[N:16][C:17]([NH2:20])=[N:18][CH:19]=3)=[CH:13][C:8]=2[N:7]=[C:6]1[C:21]1[CH:26]=[C:25]([CH2:27][CH3:28])[CH:24]=[CH:23][C:22]=1[N:29]1[CH:33]=[N:32][CH:31]=[N:30]1)([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 1

HCID 532373775-[1-tert-Butyl-2-(2-1,2,4-triazol-1-yl-5-vinyl-phenyl)-1H-benzimidazol-5-yl]-pyrimidin-2-ylamine

Product 1

HCID 532376105-[1-tert-Butyl-2-(5-ethyl-2-1,2,4-triazol-1-yl-phenyl)-1H-benzimidazol-5-yl]-pyrimidin-2-ylamineYield 31%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of 5-[1-tert-butyl-2-(2-1,2,4-triazol-1-yl-5-vinyl-phenyl)-1H-benzimidazol-5-yl]-pyrimidin-2-ylamine (100 mg, 0.23 mmol) in EtOH (5 mL) is added 10% Pd/C (10 mg) at room temperature. The reaction vessel is de-gased and is filled with H2 using a balloon. The mixture is stirred at the same temperature for 12 hours. The mixture is filtered and the filtrate is concentrated. The residue is purified by silica gel flash column chromatography eluting with 10% MeOH in CH2Cl2 to afford the title compound (31 mg, 31%) as a pale brown foam. LCMS (ESMS): m/z 439.73 (M++1)

Workup

  1. customThe reaction vessel is de-gased
  2. additionis filled with H2 using a balloon
  3. filtrationThe mixture is filtered
  4. concentrationthe filtrate is concentrated
  5. customThe residue is purified by silica gel flash column chromatography
  6. washeluting with 10% MeOH in CH2Cl2

Sources & evidence

ORD record
ord-e75ed961211447e988845bca12ddf247
Source dataset
uspto-grants-2013_04
Patent number
US08420655B2

Reaction notes

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