反应详情

To a solution of 5-[1-tert-butyl-2-(2-1,2,4-triazol-1-yl-5-vinyl-phenyl)-1H-benzimidazol-5-yl]-pyrimidin-2-ylamine (100 mg, 0.23 mmol) in EtOH (5 mL) is added 10% Pd/C (10 mg) at room temperature. The reaction vessel is de-gased and is filled with H2 using a balloon. The mixture is stirred at the same temperature for 12 hours. The mixture is filtered and the filtrate is concentrated. The residue is purified by silica gel flash column chromatography eluting with 10% MeOH in CH2Cl2 to afford the title compound (31 mg, 31%) as a pale brown foam. LCMS (ESMS): m/z 439.73 (M++1)

1. customThe reaction vessel is de-gased
2. additionis filled with H2 using a balloon
3. filtrationThe mixture is filtered
4. concentrationthe filtrate is concentrated
5. customThe residue is purified by silica gel flash column chromatography
6. washeluting with 10% MeOH in CH2Cl2