Sodium Thiosulfate → HCID 58542059, compound

Participants

Reaction Steps

To a solution of 4-(2-amino-pyrimidin-5-yl)-N1-tert-butyl-benzene-1,2-diamine (150 mg, 0.58 mmol) in DMF (5 mL) is added 2-(1H-pyrazol-4-yl)-benzaldehyde (100 mg, 0.58 mmol) at room temperature. Oxone (360 mg, 0.58 mmol) in H2O (1 mL) is added and the reaction is stirred at the same temperature for 3 hours. The reaction is poured into water (75 mL) and sodium thiosulfate (sat., 15 mL). The product is extracted into EtOAc (3×) and the combined organics are then dried (MgSO4), filtered, and concentrated. Purification via flash chromatography (12 g silica gel, 0-10% MeOH/CH2Cl2) gives the title compound (25 mg, 10%). LCMS (ESMS): m/z 410.20 (M++1)

Provenance & Evidence