Sodium Thiosulfate → HCID 58541938, compound

Participants

Reaction Steps

To a solution of 4-(2-amino-pyrimidin-5-yl)-N1-tert-butyl-benzene-1,2-diamine (64 mg, 0.25 mmol) in DMF (3 mL) is added 2-(3,5-dimethyl-pyrazol-1-yl)-benzaldehyde (50 mg, 0.25 mmol) at room temperature. Oxone (150 mg, 0.25 mmol) in H2O (1 mL) is added and the solution is stirred at the same temperature for 3 hours. The reaction is poured into water (25 mL) and sodium thiosulfate (sat., 50 mL). The product is extracted into EtOAc (2×) and the combined organics are then dried (MgSO4), filtered, and concentrated. Purification via flash chromatography (4 g silica gel, 0-6% MeOH/CH2Cl2) affords the title compound (50 mg, 46%). LCMS (ESMS): m/z 438.20 (M++1)

Provenance & Evidence