Sodium Thiosulfate → HCID 53239643, compound

Participants

Reaction Steps

To a solution of 4-(2-amino-pyrimidin-5-yl)-N1-tert-butyl-benzene-1,2-diamine (100 mg, 0.38 mmol) in DMF (3 mL) is added 5-methoxy-2-(3-methyl-pyrazol-1-yl)-benzaldehyde (90 mg, 0.42 mmol) at room temperature. Oxone (230 mg, 0.38 mmol) in H2O (1 mL) is added and the solution is stirred at the same temperature for 12 hours. The reaction is poured into water (25 mL) and sodium thiosulfate (sat., 20 mL). The product is extracted into EtOAc (3×) and the combined organics are then dried (MgSO4), filtered, and concentrated. Purification via flash chromatography (silica gel, 0-8% MeOH/CH2Cl2) affords the title compound (65 mg, 38%). LCMS (ESMS): m/z 454.20 (M++1)

Provenance & Evidence