HCID 58541954, compound → HCID 58541980, compound

Participants

Reaction Steps

To a solution of [5-chloro-2-(3-methyl-1,2,4-oxadiazol-5-yl)-phenyl]-methanol (78 mg, 0.35 mmol) in CH2Cl2 (5.0 mL) is added MnO2 (125 mg, 1.22 mmol). The reaction mixture is stirred at room temperature for 16 hours and is filtered through diatomaceous earth. The filtrate is concentrated under reduced pressure and the residue is purified by silica gel flash column chromatography with 40% EtOAc in heptanes as the eluent to afford 5-chloro-2-(3-methyl-1,2,4-oxadiazol-5-yl)-benzaldehyde (27 mg, 35%).

Provenance & Evidence